Is to stay away from anything greater than 100:1. What does it matter? I know that my bank roll and that I know for every 10k traded it's worth approx a pip (based upon the currecy pair) and that I'm liable good or poor of that. What does it matter that you need to reserve approx $100 to exchange 10k worth of this EUR/USD with 100:1 or that you need to reserve approx to exchange 10k worth of this EUR/USD with 400:1? The only issue I see is in case you didnt know the consequences and did not have the money managment skills to restrain the equity left on your account thats avaliable to use whenever you are in a trade. I adore the extra flexability and use 400:1.